Dual-energy CT quantitative parameters for evaluating Immunohistochemical biomarkers of invasive breast cancer

Cancer Imaging

Table 3 Receiver Operating Characteristic Curve Analysis of DECT Quantitative Parameters for the DifferentialDiagnosis of Immunohistochemical Factors in Invasive Breast Cancer

Parameter	AUC	Threshold of Parameter	Sensitivity (%)	Specificity (%)	Accuracy (%)
ER positive vs. negative
Venous phase NIC	0.65 [0.56, 0.75]	0.293	88.4 (76/86) [79.2, 94.0]	41.2 (14/34) [25.1, 59.2]	75.0 (90/120) [66.5, 81.9]
Venous phase nZ_eff	0.60 [0.49, 0.70]	0.87	70.9 (61/86) [60.0, 80.0]	50.0 (17/34) [32.8, 67.2]	65.0 (78/120) [56.1, 73.0]
PR positive vs. negative
Arterial phase NIC	0.63 [0.53, 0.73]	0.082	75.5 (40/53) [61.4, 85.9]	50.7 (34/67) [38.4, 61.0]	61.7 (74/120) [52.7, 69.9]
Venous phase NIC	0.65 [0.55, 0.75]	0.356	62.3 (33/53) [47.9, 74.9]	62.7 (42/67) [50.0, 73.1]	62.5 (75/161) [53.6, 70.7]
HER2 positive vs. negative
Venous phase nZ_eff	0.59 [0.49, 0.69]	0.87	70.2 (33/47) [54.9, 82.2]	53.4 (39/73) [41.4, 65.0]	60.0 (72/120) [51.1, 68.3]
Ki67 low- vs. high-proliferation
Arterial phase NIC	0.67 [0.57, 0.77]	0.079	80.0 (56/70) [68.4, 88.3]	54.0 (27/50) [39.5, 67.9]	69.2 (83/120) [60.4, 76.8]
Venous phase NIC	0.75 [0.67, 0.84]	0.281	88.6 (62/70) [78.2, 94.6]	52.0 (26/50) [37.6, 66.1]	73.3 (88/120) [64.8, 80.5]
Arterial phase nZ_eff	0.70 [0.60, 0.79]	0.73	65.7 (46/70) [53.3, 76.4]	62.0 (31/50) [47.2, 75.0]	64.2 (77/120) [55.3, 72.2]
Venous phase nZ_eff	0.67 [0.57, 0.77]	0.86	74.3 (52/70) [62.2, 83.7]	50.0 (25/50) [35.7, 64.3]	64.2 (77/120) [55.3, 72.2]

Note—Data in parentheses are numerator/denominator; data in brackets are 95% confidential intervals. NIC normalized iodine concentration; λ_Hu slope of the spectral Hounsfield unit curve; nZ_eff normalized effective atomic number; HU Hounsfield unit; AUC area under the curve

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