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Variables
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BC group (n = 17)
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HC group(n = 19)
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P value
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|---|
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Age (years)
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|
median ± (IQRs)
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46 (40–50)
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47 (36–52)
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0.505c
|
|
Education levels (years)
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|
median ± (IQRs)
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12 (9–14)
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15 (11–16)
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0.065c
|
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Premenopause, n (%)
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11 (64.7)
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11 (57.9)
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0.896b
|
|
Menopause, n (%)
|
6 (35.3)
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8 (42.1)
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0.734b
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Breast cancer stage, n (%)
|
|
I
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4 (23.5)
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NA
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NA
|
|
II
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7 (41.2)
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NA
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NA
|
|
III
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6 (35.3)
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NA
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NA
|
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Chemotherapy regimen stage (I-III)
| |
NA
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NA
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Postoperative chemotherapy, (I-III)
| | |
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AC-T (eight cycles), n (%)
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11 (64.7)
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NA
|
NA
|
|
Neoadjuvant chemotherapy, (I-III)
| | |
|
TEC (six cycles), n (%)
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5 (29.4)
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NA
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NA
|
|
AC-T (eight cycles), (IIB)
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1 (5.9)
| | |
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Clinical data, median ± (IQRs)
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|
SAS (score)
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29.0 (27.0–31.75)
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25.0 (22.8–26.0)
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0.012c
|
|
SDS (score)
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27.5 (24.5–32.0)
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23.0 (22.0–27.0)
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0.002c
|
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E2 (pmol/L)
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265.0 (112.3–391.8)
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83.0 (42.0–199.0)
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0.220c
|
|
FSH (IU/L)
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6.9 (3.9–40.1)
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26.8 (8.1–80.3)
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0.021a
|
|
LH (IU/L)
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7.3 (2.2–25.4)
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21.6 (8.3–40.6)
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0.501c
|
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Hemoglobin(g/L)
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124.0 (110.0–134.0)
|
131.0 (125.0–136.0)
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0.334c
|
|
Total cholesterol (mmol/L)
|
4.9 (4.3–5.7)
|
5.2 (4.5–5.7)
|
0.037c
|
|
Triglycerides (mmol/L)
|
1.5 (0.9–3.0)
|
0.8 (0.6–1.7)
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0.030c
|
|
Fasting glucose (mmol/L)
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5.2 (4.7–7.2)
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4.9 (4.6–5.2)
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0.005a
|
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Cognitive performance, median ± (IQRs)
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|
MMSE (score)
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28.0 (27.0–29.5)
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29.0 (28.0–30.0)
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0.061c
|
|
DST (score)
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49.5 (34.0–61.8)
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62.0 (45.0–69.0)
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0.408c
|
|
LTT (sec)
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59.8 (46.1–83.2)
|
32.3 (24.2–38.1)
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0.429c
|
|
SDT (sec)
|
37.5 (33.3–42.3)
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30.7 (27.1–34.5)
|
0.050a
|
|
WDT (score)
|
24.0 (22.0–27.0)
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27.0 (24.5–29.3)
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0.010a
|
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Stroop-C (sec)
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15.3 (13.5–18.4)
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13.8 (9.9–15.8)
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0.005a
|
|
Stroop-W (sec)
|
22.0 (18.5–26.1)
|
16.0 (13.5–18.5)
|
< 0.001c
|
|
Stroop-I (sec)
|
31.5 (24.9–33.0)
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24.3 (19.2–28.4)
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0.003c
|
- a: k-independent samples nonparametric tests; b: chi square test; c: two-sample t test
- Abbreviations: A Doxorubicin, C Cyclophosphamide, T Docetaxel, E Epirubicin, SD standard deviation, E2 estradiol, FSH follicle stimulating hormone, LH luteinizing hormone, DST digit symbol test, MMSE Mini-mental state examination, LTT line tracing test, NCT-A number connection test A, SDT serial dotting test, SDS Self-Rating Depression Scale, SAS Self-Rating Anxiety Scale, Stroop-C Stroop colour test, Stroop-D Stroop word test, Stroop-I Stroop interference test, WDT Auditory verbal learning memory
