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Characteristics
|
MVI (−)
(n = 22, %)
|
MVI (+)
(n = 14, %)
|
P-value**
|
|---|
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Age (years)
|
|
Median (range)
|
61.5 (35–74)
|
56.5 (46–73)
|
0.4
|
|
Sex
|
|
Men
|
14 (63.6)
|
10 (71.4)
|
0.6
|
|
Women
|
8 (36.4)
|
4 (28.6)
|
|
Staging of hepatic fibrosisa
|
|
0
|
1
|
0
|
0.6
|
|
1
|
1
|
1
|
|
2
|
5
|
3
|
|
3
|
6
|
3
|
|
4
|
9
|
7
|
|
Underlying liver disease
|
|
Hepatitis B
|
16 (72.7)
|
12 (85.7)
|
0.4
|
|
Hepatitis C
|
2 (9.1)
|
2 (14.3)
|
|
Alcoholism
|
2 (9.1)
|
0 (0)
|
|
Non B Non C
|
2 (9.1)
|
0 (0)
|
|
Edmondson-Steiner grade of HCC
|
|
I
|
7
|
1
|
0.06
|
|
II
|
12
|
7
|
|
III
|
3
|
6
|
|
AFP level (ng/ml)
|
|
Median (range)
|
3.02 (0.9–1387.3)
|
8.89 (2.11–2022.37)
|
0.03
|
|
PIVKA-II level (mAU/ml)
|
|
Median (range)
|
32 (16–827)
|
66 (0.74–6168)
|
0.09
|
- Abbreviations: MVI microvascular invasion, AFP Alpha-fetoprotein, PIVKA-II Protein induced by vitamin K absence or antagonist-II, SD standard deviation
- aA staging system for chronic hepatitis by the Korean Study Group for the Pathology of Digestive Diseases was used (0, no fibrosis; 1, portal fibrosis; 2, periportal fibrosis, 3, septal fibrosis; 4, cirrhosis)
- ** Continuous data were assessed using Mann-Whitney test while categorical variables were analyzed using chi square test. Staging of hepatic fibrosis, underlying liver disease, Edmondson-Steiner grade of HCC were compared as follows; stage 4 vs. stage 0–3, hepatitis B vs. others, grade III vs. grade I-II
